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Iswarya Fertility Centre & Women's Hospital
Iswarya
Fertility Centre
Female Infertility

Premature Ovarian Insufficiency (POI)

Loss of normal ovarian function before age 40, causing oestrogen deficiency and infertility. Spontaneous pregnancy is rare (5–10%).

Overview

Overview

Loss of normal ovarian function before age 40, causing oestrogen deficiency and infertility. Spontaneous pregnancy is rare (5–10%).

Symptoms

Absent or irregular periods
Hot flushes
Night sweats
Vaginal dryness
Infertility

Causes

1
Autoimmune
2
Fragile X premutation
3
Turner mosaic
4
Chemotherapy/radiation
5
Idiopathic

How It's Diagnosed

FSH (elevated >25 IU/L on two tests 4+ weeks apart)
AMH (very low)
Karyotype
FMR1 testing
Autoimmune screen

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