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Female Infertility

Antiphospholipid Syndrome (APS)

An autoimmune prothrombotic condition that causes placental microthrombi, leading to recurrent miscarriage (especially second-trimester) and thrombosis.

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Overview

An autoimmune prothrombotic condition that causes placental microthrombi, leading to recurrent miscarriage (especially second-trimester) and thrombosis.

Symptoms

Recurrent miscarriage

Stillbirth

Thrombosis (DVT/PE)

Pregnancy-related hypertension

Causes

Autoimmune: lupus anticoagulant, anti-cardiolipin, anti-β2-glycoprotein I antibodies

How It's Diagnosed

Lupus anticoagulant

Anti-cardiolipin IgG/IgM

Anti-β2-glycoprotein I IgG/IgM

Two positive tests ≥12 weeks apart

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